Confirmed bacterial prostatitis usually requires appropriate antibiotics for at least 3 weeks to 3 months besides other supportive treatment. It is also eminently associated with relapses and emergence of bacterial resistant to most if not all oral antibiotics. Unsatisfactory outcome and / or failure of treatment may mean persistent or frequent recurrent symptoms compounded with positive semen culture. Of course, one need to ensure that the semen collected is fresh and not contaminated or else the result can be misleading. As each case is unique, tailor-made treatment can only be offered after full assessment.